WebFeb 1, 2024 · In 2013, based on an untargeted metabolomic analysis, researchers first showed that trimethylamine-N-oxide (TMAO), a molecular metabolite that is derived from … WebIn anaerobiosis, Escherichia coli can use trimethylamine N-oxide (TMAO) as a terminal electron acceptor. Reduction of TMAO in trimethylamine (TMA) is mainly performed by …

TMAO: how gut microbiota contributes to heart failure

WebTMAO reductase may refer to: Trimethylamine N-oxide reductase Trimethylamine-N-oxide reductase (cytochrome c) This set index page lists enzyme articles associated with the same name. If an internal link led you here, you may wish to change the link to point directly to the intended article. Trimethylamine N-oxide reductase (TOR or TMAO reductase, EC 1.7.2.3) is a microbial enzyme that can reduce trimethylamine N-oxide (TMAO) into trimethylamine (TMA), as part of the electron transport chain. The enzyme has been purified from E. coli and the photosynthetic bacteria Roseobacter … See more TMAO reductase has an enzyme commission (EC) number of 1.7.2.3. EC numbers are a system of enzyme nomenclature, and each part of this nomenclature refers to a progressive classification of the … See more In E. coli, it has been shown that an inducible, periplasmic TMAO reductase is responsible for almost all TMAO reduction (with the rest being … See more • Unemoto T, Hayashi M, Miyaki K, Hayashi M (November 1965). "Intracellular localization and properties of trimethylamine-N … See more TMAO is an organic osmolyte that has the useful biological function of protecting proteins against denaturing stresses such as high concentration of urea. Various bacteria grow … See more In E. coli, TMAO reductase is encoded by the torCAD operon. The torC gene encodes a pentahemic c-type cytochrome (TorC). TorC is likely to … See more • Biology portal • Oxidative phosphorylation • Microbial metabolism See more • ENZYME entry for EC 1.7.2.3 • BRENDA entry for EC 1.7.2.3 See more dumowood prijs

BMC Microbiology BioMed Central

WebAug 20, 2024 · TMAO reductase is an N-oxide specific enzyme in E. coli and is responsible for reducing TMAO to TMA . Furthermore, broad-spectrum antibiotics have been shown to alter the composition of gut microbiota and lower TMAO levels, emphasizing the role of gut bacteria in TMAO synthesis [1, 6, 56] (Fig. 2). WebTMAO reductase. Purification of TMAO reductase from the mod mutant grown with tungstate Using our standard TorA purification protocol, we purified 0.5mg of TMAOR to near homogeneity from 38g of cells of the mod mutant grown with tungstate (Fig. 1). The TMAOR was purified 65-fold with a specific activity of Web地址：中国 广州市 黄埔大道西601号 版权所有©暨南大学. ICP备案号：粤ICP备 12087612号 粤公网安备 44010602001461号 dumoulin kortrijk