2024 Platinum ototoxicity

Platinum ototoxicity

Author: hdbw

August undefined, 2024

WebbUS20240087073A1 US17/957,476 US202417957476A US2024087073A1 US 20240087073 A1 US20240087073 A1 US 20240087073A1 US 202417957476 A US202417957476 A US 202417957476A US 2024087073 A1 US2024087073 A1 US 2024087073A1 Authority US United States Prior art keywords cancer complex pharmaceutically acceptable formula … WebbSodium thiosulfate interacts directly with cisplatin to produce an inactive platinum species. Regulatory Status Sodium thiosulfate (e.g., Pedmark) was approved by the U.S. Food and Drug Administration (FDA) on September 20th, 2024, to reduce the risk of ototoxicity associated with cisplatin in pediatric individuals 1 month of age and older with localized, …

[PDF] Platinum-induced ototoxicity: a review of prevailing …

Webb5 juli 2006 · Patients < 5 years at diagnosis had greater ototoxicity than older patients had, with adolescents/adults being the least affected. Findings were stable in repeated … WebbThe first major recognition of drug-induced hearing loss can be traced back more than seven decades to the development of streptomycin as an antimicrobial agent. Since then at least 130 therapeutic drugs have been recognized as having ototoxic side-effects. Two important classes of ototoxic drugs are the aminoglycoside antibiotics and the platinum … biny andrews

Non-autonomous Cellular Responses to Ototoxic Drug-Induced …

WebbOtotoxicity is a well-known adverse effect of platinum compounds, such as cisplatin and carboplatin, that may cause permanent hearing loss, tinnitus, or vestibular disturbances … WebbOur understanding of the role of cisplatin in ototoxicity is limited; however, research suggests that cisplatin uptake plays a crucial role. A recent study detected residual … Webb11 apr. 2024 · In addition, they also had a marked reduction of systemic toxicity since serum platinum, pulmonary toxicity, hepatotoxicity, and nephrotoxicity were not detected, proving their safety. Lan et al. also developed a co-loaded CISPt and anti-PD-1 (a blocker of programmed cell death protein (PD-1) NPs. daehlers wirehaired pointing griffon

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Platinum-Related Ototoxicity in Children cancer Encyclopedia MDPI

Webb19 maj 2016 · Platinum-induced ototoxicity in children: a consensus review on mechanisms, predisposition, and protection, including a new International Society of … WebbWe studied 78 pediatric patients (155 ears) with localized brain tumors treated in 1997–2001 who had not received platinum-based chemotherapy and were followed up for at least 48 months. They were evaluated prospectively by means of serial pure-tone audiograms (250 Hz–8 kHz) and/or auditory brainstem response before and every 6 … dae high energy physics symposiumWebbPlatinum-based therapy is the mainstay for management of high-risk neuroblastoma. Prevalence of platinum-related ototoxicity has ranged from 13% to 95% in previous … daehlie clothing canada

"WebbAntineoplastic lecture notes antineoplastic agents antineoplastics alkylating agents and platinum compounds common examples: alkylating agents chlorambucil (Skip to document. Ask an Expert. Sign in Register. Sign in Register. Home. Ask an Expert New. My Library. Discovery. " - Platinum ototoxicity

Platinum ototoxicity

Platinum-induced ototoxicity: a review of prevailing ototoxicity ...

Webb24 juli 2024 · Platinum chemotherapeutics and other free-radical inducing therapies, such as radiotherapy, can cause multiple systemic and neurological side effects. In children, … WebbCisplatin, carboplatin, nedaplatin, and oxaliplatin are widely used in contemporary oncology; however, their ototoxic and neurotoxic side effects are quite different as …

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WebbFor assessment of the ototoxic potential of carboplatin [cis-diammine-1,1-cyclobutane dicarboxylate platinum(II); CBDCA], pure-tone audiograms were evaluated in 27 patients … Webb13 juni 2013 · Platinum chemotherapy drugs, such as cisplatin and carboplatin, are the cornerstone of many effective therapeutic protocols for childhood cancer. However, the …

WebbSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources Webbof platinum (Pt) in industrial settings is respiratory sensitisation, often referred to as “platinum salt sensitivity” or PSS. • Not all forms of platinum are respiratory sensitisers. …

Webb16 nov. 2024 · Unfortunately, platinum-based therapies cause ototoxicity in many patients, and are particularly harmful to the survivors of pediatric cancer. Each year in the U.S. and Europe there is estimated that over 10,000 children with solid tumors are treated with platinum agents. WebbMechanistically, cisplatin ototoxicity is associated with the absence of glutathione (GSH) and the inhibition of glutathione peroxidase (GSH.Px) and glutathione reductase activities because cisplatin can covalently bind to the sulfhydryl groups of anti-oxidant enzymes, causing enzyme inactivation. 2 Increased lipid peroxidation in the cochlea …

WebbPlatinum ototoxicity was also attributed to free radical-induced cell damage, and antioxidant as well as platinum detoxifying mechanisms may protect from its …

WebbIntroduction of platinum anticancer drugs increased survival rate, and several randomized studies have been tried to establish the better combination of anticancer drugs. ... Cisplatin produces severe side effects such as neurotoxicity, ototoxicity, and nephrotoxicity in addition to myelosuppression and severe nausea. binya public schoolWebbDrugs may cause hearing loss, dysequilibrium, and/or tinnitus. Common drugs include aminoglycosides, platinum-containing chemotherapy drugs, and high-dose salicylates. … daehlie footballWebbRESEARCH TRIANGLE PARK, N.C., March 13, 2024 (GLOBE NEWSWIRE) -- Fennec Pharmaceuticals Inc. (NASDAQ:FENC; TSX: FRX), a specialty pharmaceutical company focused on the development of PEDMARKTM (a unique formulation of sodium thiosulfate (STS)) for the prevention of platinum-induced ototoxicity in pediatric patients, today … bin yang cleveland clinicWebbPlatinum levels were inversely correlated with time since diagnosis (Figure; r= -0.39). We will measure the association between blood serum platinum levels and ototoxicity, while … daehlie half zip comfyWebb17 maj 2024 · The main platinum compounds are cisplatin, carboplatin, and oxaliplatin. Their use in clinical practice has greatly improved long-term survival of pediatric … daehi new worldWebbTitle: Cisâ platinum Ototoxicity: Clinical experience and temporal bone histopathology: Created Date: 10/9/2006 5:15:09 PM binya street griffithOtotoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. There are many well-known ototoxic drugs used in clinical situations, and they are prescribed, despite the risk of hearing disorders, for very serious health conditions. Otot… daehlers wirehaired pointing griffon reviews